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The AUC of p-Ser129--Syn in diluted human serum was 0.92, suggesting its potential value as a biomarker for clinical diagnosis of early PD ( -Syn levels in patients with late-onset PD than those with early-onset disease, as well as in patients with postural instability and gait difficulties than those with tremor-predominant PD, but obviously lower in patients with cognitive deficits and olfactory loss with PD ( -Syn protofibers into the medial forebrain bundle

M., Agapite, J., White, K