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Hashimotos thyroiditis affects symptom load and quality of life unrelated to hypothyroidism: A prospective casecontrol study in women undergoing thyroidectomy for benign goiter

competitive tyrosinase substrate that redirects melanin synthesis toward lighter pheomelanin Niacinamide (Vitamin B3) Inhibits melanosome transfer from melanocytes to keratinocytes (the key step producing visible pigmentation)

doi: 10.1371/journal.pone.0138975, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 127.Liu L, Fu C, Yan M, Xie H, Li S, Yu Q, et al

Silent cerebral infarcts (SCI), which are linked to small-vessel disease, are more frequent than obvious strokes

Met activation has been extensively shown to drive proliferation, migration, invasion, and angiogenesis in HNSCC and other tumor types (16) and HGF/Met activation is a known mechanism of resistance to anti-EGFR therapy (17)