J Biol Chem 278:28532858 Li C, Matter A, Kelly A, Petty TJ, Najafi H, MacMullen C, Daikhin Y, Nissim I, Lazarow A, Kwagh J, Collins HW, Hsu BYL, Nissim I, Yudkoff M, Matschinsky FM, Stanley CA (2006) Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice
GLP-1 receptor agonists like semaglutide are increasingly covered for obesity and diabetes
Under the physiological inhibitory control of Gln synthesis by dopaminergic signaling, the enhanced Glu-Gln metabolism induced by reactive astrocytes might be one pathological factor responsible for the E/I imbalance found in autism
Research also shows that fabricated oxidized glutathione (GSSG) can be used for proteomics and other pharmaceutical uses, especially for aiding in protein synthesis and cellular repairs
In a model of brain injury induced in male rats using a fluid percussion device, researchers noted a significant increase in caspase-3-positive neurons and Neu-N plus TUNEL-positive neurons around the lesion site 72 h post-injury (Tang et al., 2016)
