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Another possibility is that there is a potent dose effect, supported by higher concentrations of e-cigarette vapor exposure in vitro causing suppression of HLA-DR (antigen presentation) and CD86 (costimulatory molecule important for T-cell activation) in LPS matured DCs, converting them from potent T-cell activators into tolerogenic or functionally impaired antigen-presenting cells

and 3) The genetic variant is not associated with confounders 26 (if the IV is correlated with other factors, the results may reflect the influence of the IV on the outcome through these factors rather than through the exposure, thereby weakening the interpretability of the findings and increasing the risk of misleading conclusions)

But from the looks of it, the joke might be on her haters

The lower cost also makes them appealing, especially for those who prioritize budget over organic credentials