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Zimmerman, M., Gottsater, A

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Emphasize the importance of avoiding strenuous physical activity, extreme temperatures, and direct manipulation of the treated area for at least 24 hours post-procedure

Thus, a larger-scale multi-center study will be considered in the future to minimize the potential interference of these factors

1418 This study provides the first direct comparison of apixaban pharmacokinetics and pharmacodynamics in healthy Japanese and Caucasian subjects matched for age, weight, and smoking status at multiple dose levels, in order to better understand the potential for ethnic influences on apixaban pharmacokinetics and pharmacodynamics