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In a paper recently published in the Journal of Dental Research (April 2025) , the researchers showed that an anti-senescence therapy or senotherapy, consisting of an enzyme inhibitor called dasatinib and a natural flavonoid plant compound called quercetin, reduced markers of senescence and associated periodontal inflammation and bone loss in lab-dish and animal models

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I never find a clear physical explanation, and I feel that leaves us with an interesting question as to whether Mpemba-like effects exist in a meaningful way. Bechhoefers trials appear to offer some insight into how the Mpemba effect could arise in systems with metastable states, but whether it is the only mechanism or how any particular substance undergoes such out-of-equilibrium heating or cooling is unknown