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GPER and thyroid diseases Epidemiological studies have indicated a marked increase in the thyroid disease incidence in recent decades, particularly among women [202], with thyroid cancer rates showing a persistent increasing trend [203]
GCK also exerts joint protection by inhibiting the proliferation, migration and secretion of synovial cells (129), whose molecular mechanism is to inhibit the secretion of TNF- in AIA-FLS rats, down-regulate the expression of tumor necrosis factor receptor type 2 (TNFR2), and inhibit TNF--mediated proliferation, migration and secretion of AIA -FLS