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Nat Clin Pract Gastroenterol Hepatol (2005) 2:41622

What they found: Preventive administration: 70 to 85 % reduction in ulcer area Therapeutic administration: 60 to 75 % reduction And now the most interesting part: 10 ng/kg worked just as well as 10 g/kg Why it matters: If the molecule worked in a stoichiometric way (= simply blocking something piece by piece), a higher dose would necessarily produce a larger effect

Clinical investigation to support new uses generally requires an Investigational New Drug (IND) application with appropriate chemistry, manufacturing, and controls, nonclinical safety, and human data

A fraction of this novel mercury-containing metabolite was analyzed by ESI-MS and revealed the formation of an ethylmercury-L-glutathione complex

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