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Environmental and lifestyle factors also contribute to disease development

Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)

It may be related to toxicity, oxidative damage, poor nutritional status or nutritional deficiencies, heavy metal or environmental toxicity, systemic disorders, hormonal imbalances, xenobiotic exposure, age-related decline, or obesity

The Global Burden of Disease Study 2010: interpretation and implications for the neglected tropical diseases

These studies highlight its efficacy in treating a wide range of conditions, from tendon and muscle injuries to gastric ulcers and central nervous system damage