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The pathophysiology of IC/BPS is poorly understood, and theories include chronic inflammation, autoimmune dysregulation, bacterial cystitis, urothelial dysfunction, deficiency of the glycosaminoglycan (GAG) barrier and urine cytotoxicity

Interlukin-22 (IL-22) Th17 and Th22 cells mediate the effect of IL-22 on IL-23-induced keratinocyte hyperproliferation in both in vivo and in vitro settings through STAT3 signaling

The presence of a catechol group in the B-ring, due to its ability to donate hydrogen, increases the formation of a relatively stable flavonoid-derived radical, which is the most important determinant of reactive oxygen and nitrogen species (RONS) inhibition (188)

Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC

Always aim at the glass wall and let water roll down to the powder