The PKC pathway becomes activated through hyperglycemia-induced increases in diacylglycerol (DAG), with PKC- and PKC- isoforms particularly implicated in stimulating NOX activity while inhibiting AMPK-mediated antioxidant responses (Geraldes and King, 2018)
Scientific References Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial
Rice D, Kim HW, Sabichi A, Lippman S, Lee JJ, Williams B, Vaporciyan A, Smythe WR, Swisher S , Walsh G, Putnam JB, Hong WK, Roth J
969988, doi:10.1163/156856208784909435
Functional status and well-being in people with myalgic encephalomyelitis/chronic fatigue syndrome compared with people with multiple sclerosis and healthy controls