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5.2.1 AMPK activation and improvement of metabolic homeostasis: metformin Metformin primarily exerts its pharmacological effects by activating AMPK and suppressing hepatic gluconeogenesis, thereby restoring glucose metabolic homeostasis

For exogenously expressed proteins, remaining supernatants were incubated overnight at 4 C with magnetic beads conjugated to anti-HA or anti-Flag antibodies

is that GDH overactivity in the brain promotes the formation of astrocytes, resulting in an imbalance between glial and neuronal cells that may lead to seizures and severe developmental defects [5]

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