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About Japan Early-stage Trial of Ultrahigh-Dose Methylcobalamin for ALS (JETALS) The Japan Early-stage Trial of Ultrahigh-Dose Methylcobalamin for ALS (JETALS) is an investigator-initiated study conducted as a multicenter, placebo-controlled, double-blind, randomized Phase III clinical trial to verify the efficacy and safety of high-dose methylcobalamin (mecobalamin) in patients with amyotrophic lateral sclerosis (ALS)

In controlled experimental models, researchers examine how such preservatives maintain sterility and prevent microbial growth over time in multi-use vials, enabling repeated access without immediate contamination

Frontiers in Bioengineering and Biotechnology, 9

D., Blher, M., Tschp, M

Exclusion criteria included the following: (1) alcohol consumption greater than 20 g/day