These diseases, including multiple sclerosis (MS), Alzheimers disease (AD) and Parkinsons disease (PD), are often characterized by progressive neuronal dysfunction and degeneration
Funding This work was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/T0083690/1)
This process was primarily driven by the abnormal proliferation of Fusobacteriota and Bacteroidota: Bacteroidota could efficiently degrade host mucins and polysaccharides, providing essential carbon and energy sources for the community, while Fusobacteriota might exploit their secreted virulence factors, such as leukotoxins and extracellular proteases, to disrupt the mucosal structure 117
This is why we view it as one component of a larger, personalized health strategy designed for lasting performance, not just a temporary fix
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