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However, protocols extending beyond 6 months in humans rely on extrapolation rather than controlled studies

Research & Evidence Disclaimer: Information presented in this article includes references to preclinical (animal and laboratory) research

In addition, purification is expensive, making it even more difficult to use in the clinic

Combination-pathway research: Commonly studied with GLP-1 receptor agonists (e.g., semaglutide) to evaluate multi-hormone effects on appetite and metabolism

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