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How to test and treat small intestinal bacterial overgrowth: an evidence-based approach

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Downregulated expression of occludin and zonula occludens-1 is related to increased matrix metalloproteinases levels in diabetes in both rats and humans [37,38], and inhibition of matrix metalloproteinase-9 prevents increased leakage in streptozotocin-induced diabetic mice [39]

And now, instead of seeking perfect isolation, we focus on creating the environment conducive to our goals, while we still carefully document the things that change