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Wang W, Leu J, Watson R, Xu Z, Zhou H (2018) Investigation of the mechanism of therapeutic protein-drug interaction between methotrexate and golimumab, an anti-tnf monoclonal antibody

Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)

doi: 10.1515/bmc-2019-0022 167

Underlying health issues: Sometimes, persistent electrolyte imbalances can indicate more serious underlying health conditions, such as kidney disease or hormonal disorders

Recently, a small phase I/IIa study of (in)GSH in PD demonstrated a mild symptomatic improvement in PD symptoms as measured by the Unified PD Rating Scale, with return of symptoms upon withdrawal of (in)GSH