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Additionally, patients on medications that affect liver enzymes, particularly those that are substrates, inhibitors, or inducers of cytochrome P450 enzymes, should be monitored for changes in drug efficacy or side effects, as glutathione may influence liver metabolism and thus the pharmacokinetics of these drugs

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis

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The mechanism for this has been observed in rat brain mitochondria