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Renal function: Dehydration secondary to gastrointestinal side effects can impair renal function, particularly in those with pre-existing kidney disease

When BPC-157 is used in ex-vivo or cell culture systems, investigators still follow biosafety guidance related to handling human or animal tissues, disposing of biological waste, and documenting any unexpected findings

FDA had previously identified a range of potential safety considerations associated with these substances, including risks related to immunogenicity, peptide-related impurities, and, in some cases, limited human exposure data