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A vitamin B12 shot is an intramuscular injection of cobalamin given directly into a muscle, usually the upper arm or glute

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PMID: 17108971 [7] HHS / FDA

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Repletion of vitamin B12 may improve response in patients resistant to antidepressants (10) , and in older adults with major depression, long-term supplementation with a combination of B12, B6, and folic acid enhanced antidepressant treatment efficacy (40)