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Conflating them produces wildly inconsistent expectations

Discussion In PD, the progressive accumulation of LB pathology across the brain follows a characteristic pattern, which starts in the brainstem and subsequently evolves to more rostral sites of the brain (Braak ascending scheme) 1

Additionally, chronic conditions such as HIV and tuberculosis have been implicated in B12 deficiency due to increased metabolic demand and altered absorption mechanisms (Green, 2017)

Researchers often need to schedule their observations and sample collections around the administration schedule, perhaps at peak concentration or trough levels, to gain a clearer picture

doi:10.1002/bmc.2933 Behera SK, Kim HW, J-E O, Park H-S (2011) Occurrence and removal of antibiotics, hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea