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A crucial unresolved issue in Lyme arthritis is the nature of the stimulus that perpetuates synovial inflammation after the apparent eradication of live spirochetes from joints with antibiotic therapy

Improve REM and deep sleep cycles , leading to better cognitive function and energy levels

This GH then acts on the liver to produce insulinlike growth factor1 (IGF1), which mediates many of its effects, including fat breakdown, protein synthesis, and metabolic improvements MOTS-C Mitochondrial-derived peptide studied for metabolic regulation and cellular energy research

And other concurrent issues can mask progress: if your sleep is poor, your iron is low, your thyroid is off, or your testosterone is suboptimal, fixing B12 alone won't solve everything

Hepatic triglyceride accumulation resulting from a complex interplay between adipose tissue and liver is a hallmark of MASLD, with insulin resistance a major pathogenic mechanism in this context