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7.5 Critical discussion of translational challenges The translation of ferroptosis-targeting agents for AD faces multiple interconnected challenges, with BBB penetration, off-target effects, long-term safety, and perturbations of iron metabolism and immune function being the most prominent

Specifically, MUFAs react with coenzyme A (CoA) under the catalysis of ACSL3 to form the intermediate product MUFA-CoA, which is inserted into the fatty acid chain of phospholipids

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Multi-target-directed ligands (MTDL) as challenging research tools in drug discovery: From design to pharmacological evaluation

Type 2 oocysts are recovered from the top half of the gradient, while although Type 1 oocysts are mainly in the bottom half, there are significant numbers of Type 2 here also