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At the transcriptional level, TGF- activates activating transcription factor 4 (ATF4) through both Smad3 and PI3KAktmTORC1 pathways [108]

6 Thus, there remains an unmet need for novel electrophilic scaffolds whose reactivity and selectivity can be rationally tuned to address protein targets of interest

Furthermore, Gclc -deficient FoB have a block in the mitochondrial electron transport chain (ETC) due to diminished complex I and II activity and thereby accumulate the tricarboxylic acid cycle metabolite succinate

Nakano T, Hsu LW, Lai CY, Takaoka Y, Inomata M, Kitano S, et al