Furthermore, ferroptosis is regulated by various processes and small molecules, including iron metabolism, lipid peroxidation (LPO), the XC-GSH-GPX4 axis, ferroptosis suppressor protein 1 (FSP1), coenzyme Q10 (CoQ10)-NAD(P)H pathway, guanosine triphosphate cycloheximide hydrolase 1, tetrahydrobiopterin (BH4)-dihydrofolate reductase pathway, autophagy, mitochondrial function, among others (Chen et al., 2021a
Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update
For instance, cytosine deaminase converts non-toxic 5-FC into the anticancer agent 5-FU [313]
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