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The most common causes of dementia include: Alzheimer's disease Vascular dementia Parkinson's disease Dementia with Lewy bodies Frontotemporal dementia Severe head injury Other less common causes include: Huntington's disease Leukoencephalopathies, diseases that affect the deeper, white-matter brain tissue Creutzfeldt-Jakob disease, a rare and fatal condition that destroys brain tissue Some cases of multiple sclerosis (MS) or amyotrophic lateral sclerosis (ALS) Multiple-system atrophy, a group of degenerative brain diseases that affect speech, movement, and autonomic function Infections such as late-stage syphilis Although all types of dementia are progressive, the term progressive dementia refers to dementias that happen rapidly, over the course of weeks or months

Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes (Caballero et al., 2007)