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Contraindications and Precautions Use of bacteriostatic water should be guided by: The prescribing information of the medication being reconstituted Institutional policies and clinical protocols Professional guidelines (pharmacy boards, nursing associations, medical societies) Individual patient factors and medical history (as determined by the treating healthcare provider) Practitioners should verify that bacteriostatic water is the appropriate diluent for the specific medication being reconstituted, as some medications may require single-dose sterile water or other specific diluents

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(Frontiers in Pharmacology, 2022) reports a half-life under 30 minutes after IM or IV administration in rodent and dog models, which is why split-dose schedules appear in the literature