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Description

Where the gaps still are

Endogenous MOTS-c levels also decline with age, which helps explain why metabolic efficiency tends to drop in our 40s and 50s regardless of diet or exercise

The peptide's effectiveness when given either continuously (daily) or intermittently (4 applications over 10 days) suggests sustained biological effects beyond the peptide's short plasma half-life

The clinical value of most of the so far described Nrf2 activators however was rather limited, mostly due to undesired interactions of these electrophiles with other cellular targets