When NNMT depletes SAM in adipocytes, epigenetic regulation is disrupted potentially locking in gene expression patterns that favor energy storage over expenditure
Acknowledgements The author apologizes to all those researchers whose work could not be cited owing to space limitations
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Taken together, in patients with sustained remission available data strongly encourage dose reduction or increase of dosing intervals over drug discontinuation, as the latter carries a substantial risk of loss of remission
Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements