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Mechanisms biologically plausible based on known growth factor and healing pathways

Although useful for studies of protein-mediated transport, for helping describe the contributions of specific proteins toward transcellular and paracellular solute and ion transport, and for high-throughput drug screening, [77, 78] extrapolation of data supporting the transport of microorganisms or large lipophilic molecules from cultured cells to the intact epithelium is at best hazardous

Because these research pathways may overlap, studying them together can provide a more complete view of how complex biological systems respond

This is particularly useful for those with chronic gastrointestinal issues

For this reason, First-in-Human trials are not only a procedural milestone in drug development