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Tight-binding inhibitors efficiently inactivate both reaction centers of monomeric Plasmodium falciparum glyoxalase 1
2 Materials and methods 2.1 Yasser number one (YN1) affinity ranking The affinity ranking of YN1 relies on the dynamic characteristics of the biological system, requiring the integration of computational and experimental data
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Experimentally, the released active agent is optionally fitted to the Korsmeyer-Peppas equation Q/Q =kt n +b where Q is the amount of active agent released at time t, Q is the overall released amount of active agent, k is a release constant of the nth order, n is a dimensionless number related to the dissolution mechanism, and b is the axis intercept, characterizing the initial burst release mechanism wherein n=1 characterizes an erosion controlled mechanism
This is usually mild and resolves on its own
