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According to the International Scientific Association of Probiotics and Prebiotics (ISAPP), a probiotic is defined as the adequate administration of living microorganisms that confer a benefit on the host (170)

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In mice fed a high-fat high-cholesterol diet, curcumin protected against the development of gallstones, and its effect was enhanced with the addition of piperine, an alkaloid from black pepper (Li 2015)

X-ray crystallographic studies have demonstrated that copper coordination occurs through the N-terminal amino group of glycine, the deprotonated peptide nitrogen of the Gly-His bond, and the imidazole nitrogen of histidine, forming a square-planar geometry characteristic of Cu(II) complexes