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[25] A 2017 review reported that daily riboflavin taken at 400 mg per day for at least three months may reduce the frequency of migraine headaches in adults

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With aging, multiple structural and functional alterations such as decreased cerebrovascular pulsatility, reduced aquaporin-4 polarization on astrocyte end feet, and impaired perivascular cerebrospinal fluid exchange significantly reduce glymphatic efficiency

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