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Although these medications remain indispensable in the treatment of infectious diseases, their widespread use, often without appropriate indications or as part of irrational polypharmacy, has contributed to both the increasing incidence of ADRs and the accelerating emergence of antimicrobial resistance (AMR) [120, 139]

Aug 2021;95(2):229-238

The principles of peptide stacking apply here, though autoimmune applications require particular caution and careful monitoring

Impairment of the blood-testis barrier (BTB), essential for maintaining the testicular microenvironment, is a significant contributor to Leydig cell damage [54]