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Chain elongation of the intermediate is mediated by a condensation (C) domain catalyzing the nucleophilic attack of the downstream PCP-bound acceptor monomer on the activated thioester of the upstream PCP-bound donor monomer 13 , thus giving rise to the dipeptide intermediate D- O -Leu-D-Ala- S -PCP

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2.5 Harvesting of primary organs and colon tissues On the 15th day of the experiment, euthanasia was carried out on all the mice