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Lack of sleep, stress from work and trying to keep up with society's commitments often mixed with poor nutrition and lifestyle habits can lead to constipation, lack of nutrient absorption, inflammation, bloating and weight changes

In some cases, independent testing has revealed contaminants, degraded compounds, or dosages that are significantly higher or lower than advertised

Reports of adverse effects have included nausea, vomiting, stomach pain, fainting, headache, dehydration, gallstones, and inflammation of the pancreas

Furthermore, folic acid (the pharmaceutical form of folate) has been shown to improve the function of the layer of cells lining the blood vessels (Antoniades et al, 2006)