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First, the included studies exhibited significant variability in design, e-cigarette product types, usage patterns, and population characteristics

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The majority of NTP studies have been conducted with the Fischer344/N (F344) rat and the B6C3F1/N mouse (a hybrid of the C57BL/6 and C3H parental strains)

PMID 12241986

The economic burden is particularly high in the developing world - in 2030, 4 to 5 correlated with tobacco deaths worldwide will be identified in these areas