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The success of G12C inhibitors fundamentally changed the perception of KRAS from an "undruggable" target to a clinically actionable oncogenic driver and established the foundation for subsequent KRAS-targeted drug development

10.1021/bi960737u 59 MojzikovaR.KoralkovaP.HolubD.ZidovaZ.PospisilovaD.CermakJ.et al (2014)

Severe thiamin deficiency, which is rare in industrialized nations, except in patients with chronic alcoholism, HIV-AIDS, or gastrointestinal conditions that impair vitamin absorption (23), results in the condition called beriberi, of which there are many forms that involve neurological symptoms

Autoxidation of linalyl acetate, the main component of lavender oil, creates potent contact allergens

Research indicates it may support collagen cross-linking and stabilization through its role as a cofactor in hydroxylation reactions