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Furthermore, certain variants of the ACE gene, such as the D allele, are more frequently noted in patients with affective disorders and associated with a higher risk of affective disorders (63)

This inhibition leads to the accumulation of PLOOH, a surge in ROS, and ultimately drives GBM cells into ferroptosis

Cell 133:235249

these loci presumably act in part by regulating uric acid production and, in some cases, renal urate disposition

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