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Similarly, in 5FAD transgenic mice, GPX4 overexpression improves cognition, reduces neurodegeneration, lowers LPO levels, and decreases A production (300)

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The end products of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), are themselves reactive and can further propagate oxidative damage [33]

Bcl-2 protects cells from dying