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In addition, resveratrol increased the ovarian follicular reserve and prolonged the ovarian life span in rats (49) by increasing AMH levels and reducing ovarian inflammation through SIRT1 regulation among other mechanisms, leading to the inhibition of the pro-inflammatory NF-KB pathway

89,90,91,92 Zhu, et al

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Phase I study of mTORC1/2 inhibitor sapanisertib (CB-228/TAK-228) in combination with metformin in patients with mTOR/AKT/PI3K pathway alterations and advanced solid malignancies

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