Nrf2, a member of the capncollar family of basic regionleucine zipper transcription factors involved in transcription of antioxidant genes in response to xenobiotic stress, is also a critical regulator of cellular oxidative stress in sepsis (Kolls, 2006) and a regulator of exacerbated proinflammatory cytokine release (cytokine storm) and loss of T lymphocytes (leukopenia) that characterize the most aggressive presentation of SARS-CoV-2-mediated COVID-19 infection (Kobayashi et al., 2016
Sikiric et al., 2018), and its role in the braingut and gutbrain axis (Sikiric et al., 2016), along with its CNS-disturbances therapy (Sikiric et al., 2016) and stress disorders (Sikiric et al., 2017
Additionally, enhanced amino acid catabolism, as observed in mouse models of dietary deprivation 99 , may contribute to sustaining metabolic demands during fasting
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Liu J, Wang M, Tian X, Wu S, Peng H, Zhu Y, et al
