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Figure 7 4 Discussion Mounting evidence indicates the important role of the complex interaction between metabolic networks and the immune system in modulating autoimmunity responses (5053) and in facilitating the etiopathology of multiple conditions such as cancer and neurodegenerative diseases (54, 55)

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It is currently being studied as a combination therapy with GLP-1 receptor agonists , such as semaglutide and retatrutide, showing synergistic effects in weight management trials

Despite the increased LPS translocation into the blood described in numerous pathologies, it is not clear whether blood endotoxin levels are the result of LPS from the lumen or whether LPS is released by whole bacteria translocated in the lamina propria by the wall breakdown from effective host defense mechanisms and by autolysis (26)

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