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Oxidized Glutathione Is Used as a Measure of Cellular Toxicity

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For example, glucose oxidase-engineered Cu + coordination polymer nanoplatforms remain inert under basal conditions but are selectively activated by high intracellular GSH

Antioxidants, 9(5), 441

It has been shown that HSYA was able to significantly protect the liver from oxidative stress by increasing the activities of antioxidant enzymes, upregulating the expression of PPAR- and MMP-2, and downregulating the expression of TGF-1 and tissue inhibitor of metalloproteinases-1 (TIMP-1), and reducing -SMA level, which indicating that PPAR-TGF-1 would be a signal pathways for HSYA to reduce liver fibrosis induced by oxidative stress (Wang et al., 2013)