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Apart from environmental factors, genetic factors also play a role in the development of Parkinson's disease, with several genes implicated in its pathogenesis

Western blotting Total protein was extracted from paraformaldehyde-fixed, paraffin-embedded pancreatic tissues using the FFPE Total Protein Extraction Kit (Sangon Biotech, Shanghai, China) or from cultured PSCs using RIPA Lysis Buffer (Beyotime)

OAA is then converted to malic acid, which in turn generates NADPH through ME1

Similarly, the computed structures of the less active 50a and 50c exhibit an energetic preference towards an upward BCHep conformation, whereas the most active 50b is downwards, consistent with the the solid-state structures (Supplementary Fig

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