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When there are disruptions in the natural oxidation process, highly unstable and potentially damaging molecules called free radicals are created
(2012) investigated the effects of RPM supplementation (Mepron) in grazing beef heifers during late gestation and reported similar results in maternal BW, BCS, and plasma amino acid concentrations, suggesting a limited response to supplemental AA due to the limitation of energy and the weight loss occasioned by the pasture quality
Homoeostatic systems associated with astrocytes in healthy tissue also support neuroprotection after insults, for example by supplying neurones with energy substrates in ischaemic conditions, scavenging reactive oxygen species (astroglia are the main source of glutathione), removing excess glutamate and buffering K + ions, thus containing excitotoxicity, and actively taking up or detoxifying various toxic agents
More commonly, variations in bioavailability are due to metabolism during absorption
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