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[1] It functions as a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

Supporting endogenous release rather than supplying exogenous GH, it offers a more physiologic, regulated approach

252,253 It was FDA-approved for this indication in May 2023

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As a bioactive metabolite, TMAO can activate various intracellular signaling cascades, including the MAPK and NF-B pathways, the NLRP3 inflammasome, and PERK signaling as wellmechanisms closely linked to chronic inflammation (Figures 2, 3, and 4)