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Petersburg Institute of Bioregulation and Gerontology studied Epithalon across several decades, publishing findings in journals including Annals of the New York Academy of Sciences and Neuro Endocrinology Letters

Importantly, this study identified novel candidate genes linked to insulin secretion and T2D risk: ERO1B (ER stress and protein folding), HNRNPA2B1 (an RNA-binding protein regulating insulin levels), and RHOBTB3 (involved in secretory protein trafficking), whose inhibition reduced intracellular insulin ( 4 Pancreasmicrobiota interactions The application of multi-omics approaches to the study of the pancreas provides the foundation for developing personalized therapeutic strategies tailored to the molecular and cellular profiles of individual patients (Mou et al., 2025)

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