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In esophageal injury models, BPC-157 normalizes sphincter function by increasing pressure in both the lower esophageal sphincter (LES) and pyloric sphincter (PS) in animals with sphincter dysfunction, while in healthy animals the peptide demonstrates adaptive effects that maintain physiological sphincter tone

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Genes related to the auxin carrier were downregulated after treatment, while the transcription inhibitory factor AUX/IAA was upregulated

Photographs were taken in 35 mm petri dishes containing 7 mL of PBS