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Specifically, it improves HbA1c levels (an indicator of long-term blood sugar control) and insulin resistance (meaning your cells can use insulin more effectively, leading to less glucose storage and lower blood glucose levels).19 According to a 2021 animal study, berberine supplementation can slow the progression from prediabetes to type 2 diabetes.20 Some studies also suggest that taking berberine in addition to prescription medication like metformin could result in greater glycemic control;21 more definitive research is needed to support this theory, but even newer studies have found berberine to have this assistive effect.54 Also, its worth noting that berberine could potentially be a good alternative for people who cant take diabetes medication due to liver, kidney, or heart disease